Multiple hepatocellular carcinoma: Long-term outcomes following resection beyond actual guidelines. An Italian multicentric retrospective study

AbstractBackground Hepatocellular carcinoma (HCC) is frequently diagnosed as multinodular. This study aims to assess prognostic factors for survival and identify patients with multiple HCC who may benefit from surgery beyond the Barcelona Clinic Liver Cancer classification indications. Methods retrospective included all consecutive 4 Italian tertiary centers receiving liver resection naive between 1990 2012 have a potential follow-up of 5 years. Results Included were 144. Ninety-day morbidity mortality rates 38.3% 8.3%, respectively. The 5-year overall disease-free 33.3% 19.1%, Tumor size <3 cm, bilirubin, Child-Pugh A, BCLC-A stage, being within "up-to-7" criteria, minor resections resulted in factors. score an independent factor. Conclusions Surgery be related good outcomes selected HCC.